Widengård I, Mäepea O, Alm A
Department of Ophthalmology, University Hospital, Uppsala, Sweden.
Br J Ophthalmol. 1998 Apr;82(4):404-6. doi: 10.1136/bjo.82.4.404.
To investigate the effect on intraocular pressure (IOP) and aqueous flare of topical applications of latanoprost and dipivefrin alone or combined.
22 patients with open angle glaucoma or ocular hypertension were included in a 4 week open label study. Median age was 68 years (range 50-79). They were allocated to either 2 weeks' treatment with once daily evening administration of latanoprost monotherapy (50 micrograms/ml) or twice daily dipivefrin monotherapy (1 mg/ml), followed by 2 weeks' combination therapy with both drugs.
Latanoprost alone reduced IOP from 19.3 (SD 1.4) to 14.8 (0.9) mm Hg (p < 0.01). Addition of dipivefrin caused a further reduction to 12.4 (0.9) mm Hg (p < 0.01 compared with latanoprost alone). In the group where the treatment started with dipivefrin IOP was reduced from 22.3 (1.2) to 18.4 (1.0) mm Hg (p < 0.01) and with the combination to 14.9 (0.9) mm Hg (p < 0.01). No change in aqueous flare was observed with either drug, alone or in combination. A slight increase in conjunctival hyperaemia was observed when the two drugs were combined.
Latanoprost and dipivefrin have an additive effect on IOP and no clinically significant effect on the permeability to proteins of the blood-aqueous barrier. This implies that the two drugs can be a useful combination for the treatment of glaucoma.
研究单独使用或联合使用拉坦前列素和地匹福林局部应用对眼压（IOP）和房水闪光的影响。
22例开角型青光眼或高眼压症患者纳入一项为期4周的开放标签研究。中位年龄为68岁（范围50 - 79岁）。他们被分配接受为期2周的治疗，其中一组每晚一次给予拉坦前列素单药治疗（50微克/毫升），另一组每日两次给予地匹福林单药治疗（1毫克/毫升），随后为期2周的两种药物联合治疗。
单独使用拉坦前列素可使眼压从19.3（标准差1.4）降至14.8（0.9）毫米汞柱（p < 0.01）。加用地匹福林后眼压进一步降至12.4（0.9）毫米汞柱（与单独使用拉坦前列素相比p < 0.01）。在以地匹福林开始治疗的组中，眼压从22.3（1.2）降至18.4（1.0）毫米汞柱（p < 0.01），联合用药后降至14.9（0.9）毫米汞柱（p < 0.01）。单独或联合使用这两种药物均未观察到房水闪光有变化。两种药物联合使用时观察到结膜充血略有增加。
拉坦前列素和地匹福林对眼压有相加作用，对血 - 房水屏障的蛋白质通透性无临床显著影响。这意味着这两种药物联合使用可能是治疗青光眼的有效组合。
