Lalkin A, Loebstein R, Addis A, Koren G
Hospital for Sick Children, Toronto.
Can Fam Physician. 1998 Jun;44:1245-7.
QuestionQuite a few of my pregnant patients have hypertensive disorders. What is the threshold for treating hypertension during pregnancy? Which of the various antihypertensive agents are considered safe during pregnancy?AnswerPharmacologic therapy could benefit mother and baby when diastolic pressure exceeds 110 mm Hg. Preeclampsia must be followed closely. Methyldopa (eg, Aldomet) and hydralazine (eg, Apresoline) are still the drugs of choice during pregnancy, although the safety and efficacy of calcium channel blockers and Beta-blockers appear well established.
问题
我的不少孕妇患者患有高血压疾病。孕期治疗高血压的阈值是多少？各种抗高血压药物中，哪些在孕期被认为是安全的？
答案
当舒张压超过110毫米汞柱时，药物治疗可能对母婴有益。必须密切监测先兆子痫。甲基多巴（如爱道美）和肼屈嗪（如阿普利素灵）仍是孕期的首选药物，尽管钙通道阻滞剂和β受体阻滞剂的安全性和有效性似乎已得到充分证实。
