Misteli T, Spector D L
Cold Spring Harbor Laboratory, New York 11724, USA.
Curr Opin Cell Biol. 1998 Jun;10(3):323-31. doi: 10.1016/s0955-0674(98)80007-0.
Recent cell biological observations have provided new insights into how transcription, pre-mRNA splicing and 3' processing are organized and coordinated with each other in the mammalian cell nucleus. Morphological observations are supported by biochemical evidence that suggests physical interactions between components of the transcription and RNA processing machineries. A working model of the cellular organization of gene expression is now emerging.
最近的细胞生物学观察为转录、前体mRNA剪接和3' 加工在哺乳动物细胞核中如何组织和相互协调提供了新的见解。形态学观察得到了生化证据的支持，这些证据表明转录和RNA加工机制的组分之间存在物理相互作用。一个基因表达细胞组织的工作模型正在形成。
