Papla B, Dubiel-Bigaj M
Department of Experimental and Clinical Pathomorphology, CMUJ, Kraków.
Pol J Pathol. 1998;49(1):27-34.
The authors have described eleven cases of tracheobronchial amyloidosis, in 6 men and 5 women with a mean age of 58.7 years. The follow-up period ranged from several month to six years. The clinical picture and histopathological changes in bronchoscopic and postmortem sections in two patients were described. In all cases immunohistochemical examinations for the presence of amyloid AA, AL, transthyretin (prealbumin) and beta 2-microglobulin were performed. In six cases the presence of transthyretin was found. The remaining reactions were negative. Resorptive giant cells reaction to amyloid was observed in 3 transthyretin positive cases and 1 transthyretin negative case. Four cases with negative amyloid in the examination for the presence of transthyretin accompanied bronchial carcinoma, all these cases were men with a mean age of 63.0 years.
作者描述了11例气管支气管淀粉样变病例，其中男性6例，女性5例，平均年龄58.7岁。随访时间从数月至6年不等。描述了2例患者支气管镜检查及尸检切片中的临床表现和组织病理学变化。所有病例均进行了淀粉样蛋白AA、AL、转甲状腺素蛋白（前白蛋白）和β2微球蛋白的免疫组化检查。6例发现有转甲状腺素蛋白。其余反应均为阴性。在3例转甲状腺素蛋白阳性病例和1例转甲状腺素蛋白阴性病例中观察到对淀粉样蛋白的吸收性巨细胞反应。4例转甲状腺素蛋白检查淀粉样蛋白阴性的病例伴有支气管癌，所有这些病例均为男性，平均年龄63.0岁。
