Gałazka A, Wysokińska T
Zakład Badania Surowic i Szczepionek Państwowego Zakładu Higieny w Warszawie.
Postepy Hig Med Dosw. 1998;52(2):157-72.
Continuously increasing number of available vaccines and a wide use of mass vaccination campaigns lead to the development of simpler methods of vaccine delivery. There is the WHO-sponsored project, including several scientific groups, which aims to reduce the number of repeated administrations of vaccines required for long-term protection and to obviate the need for booster immunization. Such a task may be achieved by the use of controlled-release parenteral systems. One such delivery system comprises microspheres constructed from biodegradable, biocompatible polymers based on poly lactic/glycolic acid. Recent developments of a single-shot tetanus toxoid, encapsulated in the biodegradable polymeric microspheres or microcapsules are reviewed. There are promising advances in the WHO-sponsored project. However, further efforts are needed to elaborate an affective late release of antigen and to obtain a strong booster effect in vaccinated animals.
可用疫苗数量的不断增加以及大规模疫苗接种运动的广泛开展，促使了更简便的疫苗递送方法的发展。世界卫生组织发起了一个项目，其中包括几个科学小组，旨在减少长期保护所需的疫苗重复接种次数，并消除加强免疫的必要性。通过使用控释肠胃外给药系统或许可以实现这一任务。一种这样的递送系统包括由基于聚乳酸/乙醇酸的可生物降解、生物相容性聚合物构建的微球。本文综述了包裹在可生物降解聚合物微球或微胶囊中的单次破伤风类毒素的最新进展。世界卫生组织发起的这个项目取得了一些有前景的进展。然而，还需要进一步努力来精心设计抗原的有效缓释，并在接种疫苗的动物身上获得强烈的加强免疫效果。
