[国立卫生科学研究所的雌二醇参考标准品（对照品961）]
[Estradiol Reference Standard (Control 961) of National Institute of Health Sciences].
作者信息
Kitajima A, Tagashira Y, Maekawa K, Yoshii K, Komatsu H, Tanimoto T, Okada S
出版信息
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1997(115):187-9.
The raw material for estradiol was examined for preparation of the "Estradiol Reference Standard (Control 961)" of National Institute of Health Sciences. Analytical data obtained were as follows: melting point, 179.1 degrees C; UV spectrum, lambda max = 281 nm; IR spectrum, the same as that of the Estradiol Reference Standard of National Institute of Health Sciences (Control 931); optical rotation, [alpha]20D = +79.5 degrees; thin-layer chromatography, one impurity was detected; high-performance liquid chromatography (HPLC), a trace amount of three impurities were detected; loss on drying, 3.17%; assay, 99.4% by UV spectrophotometry and 99.0% by HPLC. Based on the above results, the raw material was authorized as the Estradiol Reference Standard (Control 961) of National Institute of Health Sciences.
对雌二醇的原料进行了检测，以制备国立卫生科学研究所的“雌二醇参考标准品（对照品961）”。获得的分析数据如下：熔点，179.1℃；紫外光谱，λmax = 281nm；红外光谱，与国立卫生科学研究所的雌二醇参考标准品（对照品931）相同；旋光度，[α]20D = +79.5°；薄层色谱法，检测到一种杂质；高效液相色谱法（HPLC），检测到痕量的三种杂质；干燥失重，3.17%；含量测定，紫外分光光度法为99.4%，HPLC法为99.0%。根据上述结果，该原料被批准为国立卫生科学研究所的雌二醇参考标准品（对照品961）。
Zotero 插件