Schnapp BJ, Arn EA, Deshler JO, Highett MI
Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA
Semin Cell Dev Biol. 1997 Dec;8(6):529-40. doi: 10.1006/scdb.1997.0178.
The transport and localization of mRNAs within Xenopus oocytes contributes to an asymmetry that determines axis formation in the embryo. Several mRNAs become localized along the animal-vegetal axis. The mitochondrial cloud, a specialized cytoplasmic compartment which contributes to the formation of germ plasm, and the endoplasmic reticulum play important roles in sorting and localizing these RNAs. As in other species and cell types, the localization of RNAs in Xenopus oocytes is directed by signals in the 3' untranslated regions of the transcripts. Cytoplasmic proteins that interact with these signals are being identified, as are the links between RNA localization, intracellular organelles and early embryonic development.Copyright 1997 Academic Press Limited.
非洲爪蟾卵母细胞内mRNA的运输和定位导致了一种不对称性，这种不对称性决定了胚胎中的轴形成。几种mRNA沿着动物-植物轴定位。线粒体云是一种有助于生殖质形成的特殊细胞质区室，内质网在这些RNA的分选和定位中发挥重要作用。与其他物种和细胞类型一样，非洲爪蟾卵母细胞中RNA的定位由转录本3'非翻译区的信号引导。与这些信号相互作用的细胞质蛋白正在被鉴定出来，RNA定位、细胞内细胞器和早期胚胎发育之间的联系也是如此。版权所有1997年学术出版社有限公司。
