Karino T, Sugimura S, Okimoto N, Soejima R
Department of Medicine, Kawasaki Medical School Kawasaki Hospital.
Kansenshogaku Zasshi. 1998 May;72(5):557-60. doi: 10.11150/kansenshogakuzasshi1970.72.557.
A 43-year-old female with spherocytosis was admitted to the hospital because of fever, headache, and rapidly progressive anemia. On admission, she had severe anemia (Hb 3.9 g/dl) with marked decrease in reticulocytes (0.3%). Some premature leukocytes, such as promyerocyte, were observed in the peripheral blood. Bone marrow smear revealed normocellular marrow with normal presence of erythroid cells. Anti-human parvovirus B19 IgM and IgG antibody was positive in the serum on admission. The DNA of the virus was also detected in the peripheral blood by PCR assay. Thus, this case was diagnosed as acute aplastic crisis caused by human parvovirus B19 infection. Blood transfusion was performed on day 1 and day 2. The symptoms gradually disappeared and increase in reticulocyte (11.5%) was observed on day 5. Premature leukocytes in the peripheral blood disappeared on day 2. She recovered from anemia and was discharged on day 7.
一名43岁的球形红细胞增多症女性因发热、头痛和快速进展性贫血入院。入院时，她患有严重贫血（血红蛋白3.9g/dl），网织红细胞显著减少（0.3%）。外周血中观察到一些早幼粒细胞等幼稚白细胞。骨髓涂片显示骨髓细胞数量正常，红系细胞存在正常。入院时血清中抗人细小病毒B19 IgM和IgG抗体呈阳性。通过PCR检测在外周血中也检测到了该病毒的DNA。因此，该病例被诊断为人细小病毒B19感染引起的急性再生障碍危象。在第1天和第2天进行了输血。症状逐渐消失，第5天观察到网织红细胞增加（11.5%）。外周血中的幼稚白细胞在第2天消失。她从贫血中康复，于第7天出院。
