Nishiyama Y
Department of Ohtsu Municipal Hospital, Otorhinolaryngology.
Nihon Jibiinkoka Gakkai Kaiho. 1998 May;101(5):615-9. doi: 10.3950/jibiinkoka.101.5_615.
In order to clarify the mechanism of positive scintigraphy with Tc pertechnetate in adenolymphomas of the parotid gland, 10 cases of adenolymphoma were studied morphologically and from a functional view point. Salivary tissue obtained from normal parotid glands were also investigated for comparison with the tumor. In morphological studies, rapid tissue fixation by microwave irradiation produced very good results for examining mitochondria by high resolution light microscopy. A number of mitochondria were found both in the epithelial cells of adenolymphoma and in the striated duct cells of the parotid gland. In functional studies, the one-step method of enzymatic histochemistry was used for detecting Na-K ATPase. Na-K ATPase was found on the baso-lateral side of the epithelial cells of adenolymphoma and the striated duct cells of the parotid gland, and this activity of Na-K ATPase may enhance the accumulation of Tc pertechnetate in these cells. These observations may provide evidence for the bi-cellular theory which indicates that adenolymphoma originated from immature intercalated duct reserve cells.
为阐明高锝酸盐在腮腺腺淋巴瘤中呈阳性闪烁显像的机制，从形态学和功能角度对10例腺淋巴瘤进行了研究。还对取自正常腮腺的唾液组织进行了研究，以便与肿瘤组织作比较。在形态学研究中，通过微波辐射进行快速组织固定，对于用高分辨率光学显微镜检查线粒体产生了很好的效果。在腺淋巴瘤的上皮细胞和腮腺的纹状管细胞中均发现了许多线粒体。在功能研究中，采用酶组织化学一步法检测钠钾ATP酶。在腺淋巴瘤的上皮细胞和腮腺的纹状管细胞的基底外侧发现了钠钾ATP酶，钠钾ATP酶的这种活性可能会增强高锝酸盐在这些细胞中的积聚。这些观察结果可能为双细胞理论提供证据，该理论表明腺淋巴瘤起源于未成熟的闰管储备细胞。
