Claahsen H L, Semmekrot B A, van Dongen P W, Mattijssen V
Department of Neonatology, University Hospital St. Radboud, Nijmegen, The Netherlands.
Am J Perinatol. 1998 May;15(5):295-7. doi: 10.1055/s-2007-993946.
Chemotherapeutic agents administered to the mother during pregnancy may severely jeopardize the fetus. We describe a newborn girl who had been exposed to idarubicin and cytosine-arabinoside during the second and third trimesters of pregnancy due to treatment of newly diagnosed acute myeloid leukemia in the mother. The child had no structural congenital abnormalities. Adverse effects observed were prematurity, growth retardation, mildly disturbed transaminases and erythroblastosis, all of which were self-limiting with no permanent sequelae.
孕期给予母亲的化疗药物可能会严重危及胎儿。我们描述了一名新生女婴，其母亲因新诊断的急性髓系白血病接受治疗，在妊娠中期和晚期接触了伊达比星和阿糖胞苷。该患儿无先天性结构异常。观察到的不良反应有早产、生长发育迟缓、转氨酶轻度异常和新生儿溶血病，所有这些均为自限性，无永久性后遗症。
