Buyle S, Wyndaele J J, D'Hauwers K, Wuyts F, Sys S
Department of Urology, University of Antwerp, UIA, Belgium.
Eur Urol. 1998;33(5):507-10. doi: 10.1159/000019645.
Parameters of current for transurethral intravesical electrostimulation (IVES) are studied in the rat to determine the settings which elicit optimal detrusor contractions. Action mechanisms related to the induction of detrusor contractions upon ives are also investigated.
In 24 female Wistar rats transurethral IVES was performed using 95 combinations of different pulse durations and frequencies. The reference electrode was positioned in the bladder, in the urethra, or on the abdominal wall.
The optimal detrusor contractions are induced in the rat with a current of 10 Hz frequency and 20 ms pulse duration. A mathematical correlation is found between frequency and pulse duration which permits to determine the best combination. Evidence for the existence of local factors inducing detrusor contractions by IVES is given. The detrusor contractions proved independent of the position of the reference electrode.
在大鼠中研究经尿道膀胱内电刺激（IVES）的电流参数，以确定能引起最佳逼尿肌收缩的设置。还研究了与IVES诱导逼尿肌收缩相关的作用机制。
对24只雌性Wistar大鼠进行经尿道IVES，采用95种不同脉冲持续时间和频率的组合。参考电极置于膀胱、尿道或腹壁上。
在大鼠中，频率为10Hz、脉冲持续时间为20ms的电流可诱导出最佳逼尿肌收缩。发现频率与脉冲持续时间之间存在数学相关性，这有助于确定最佳组合。给出了存在局部因素通过IVES诱导逼尿肌收缩的证据。逼尿肌收缩被证明与参考电极的位置无关。
