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从苏格兰索尔西特湖的有害颤藻水华中分离出的两种含(Z)-脱氢丁胺的微囊藻毒素。

Two (Z)-dehydrobutyrine-containing microcystins from a hepatotoxic bloom of Oscillatoria agardhii from Soulseat Loch, Scotland.

作者信息

Sano T, Beattie K A, Codd G A, Kaya K

机构信息

Environmental Chemistry Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan.

出版信息

J Nat Prod. 1998 Jun 26;61(6):851-3. doi: 10.1021/np980047m.

DOI:10.1021/np980047m
PMID:9644085
Abstract

Two (Z)-dehydrobutyrine(Dhb)-containing microcystins, [d-Asp3, (Z)-Dhb7]microcystin-HtyR (1) and [d-Asp3, (Z)-Dhb7]microcystin-LR (2), were isolated from a hepatotoxic bloom of the cyanobacterium Oscillatoria agardhii from a freshwater lake in Scotland. The geometrical structure of the Dhb units in the microcystins was determined as Z on the basis of NOE and ROESY experiments.

摘要

从苏格兰一个淡水湖的有毒蓝藻颤藻的肝毒性水华中分离出两种含（Z）-脱氢丁酸（Dhb）的微囊藻毒素，[d-天冬氨酸3，（Z）-Dhb7]微囊藻毒素-HtyR（1）和[ d-天冬氨酸3，（Z）-Dhb7]微囊藻毒素-LR（2）。基于NOE和ROESY实验，确定微囊藻毒素中Dhb单元的几何结构为Z型。

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