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视网膜变性小鼠对矩形方向的视觉敏感性。

Visual sensitivity to orientation of rectangles in mice with retinal degeneration.

作者信息

Schnitzer S B, Beane M E

出版信息

Dev Psychobiol. 1976 Mar;9(2):167-74. doi: 10.1002/dev.420090209.

DOI:10.1002/dev.420090209
PMID:964460
Abstract

C3H/HeJ male mice, an inbred strain showing retinal degeneration (rd), and normal-eyed DBA/IJ male mice were studied in a task requiring discrimination of horizontally and vertically oriented rectangles. The apparatus was modified Yerkes discrimination apparatus. The mice were given 30 days of discrimination training, 10 trials/day, after which 10 more trails were given on the 31st day with positive and negative cues reversed. Both strains showed a highly significant decrease in errors during acquisition, the rd strain making significantly fewer errors than the DBA/IJ animals. Reversal of the cues brought about a sharp increase in percentage of errors.

摘要

对C3H/HeJ雄性小鼠(一种表现出视网膜变性(rd)的近交系)和正常眼睛的DBA/IJ雄性小鼠进行了一项任务研究,该任务要求区分水平和垂直方向的矩形。实验装置为改良的耶基斯辨别装置。小鼠接受了30天的辨别训练,每天10次试验,之后在第31天又进行了10次试验,此时正性和负性线索颠倒。两种品系在习得过程中错误率均显著降低,rd品系的错误明显少于DBA/IJ动物。线索颠倒导致错误百分比急剧增加。

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引用本文的文献

1
Circadian photoreception in the retinally degenerate mouse (rd/rd).视网膜退化小鼠(rd/rd)中的昼夜节律光感受
J Comp Physiol A. 1991 Jul;169(1):39-50. doi: 10.1007/BF00198171.