Kudriashova I V, Kudriashov I E
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Mar-Apr;48(2):222-8.
Vasopressin effects were compared in hippocampal slices of control and conditioned rats. Continuous presentation both of paired and unpaired conditioned and unconditioned stimuli induced an increase in sensitivity of hippocampal neurons to vasopressin. This effect consisted in a complex biphasic reaction (excitatory-inhibitory modulation of population spike amplitude) to peptide application similar to the reaction of the control slices to the increased peptide concentration. The excitatory increased with the number of stimuli presentations and did not depend on the factor of learning. The inhibitory phase increased to a greater extent with the number of paired stimulations. It is suggested that the enhancement of depression by vasopressin in the trained animals in comparison with the active control most probably results from intracellular Ca2+ accumulation during conditioning.
在对照大鼠和条件反射大鼠的海马切片中比较了加压素的作用。成对和不成对的条件刺激和非条件刺激的持续呈现均诱导海马神经元对加压素的敏感性增加。这种效应表现为对肽应用的复杂双相反应（群体峰电位幅度的兴奋性 - 抑制性调制），类似于对照切片对增加的肽浓度的反应。兴奋性随刺激呈现次数增加而增加，且不依赖于学习因素。抑制相在成对刺激次数增加时增加得更多。有人提出，与活性对照相比，训练动物中加压素导致的抑制增强很可能是由于条件反射过程中细胞内Ca2+积累所致。
