Freire Castroseiros E, Penas Lado M, Castro Beiras A
Servicio de Cardiología, Hospital Juan Canalejo, La Coruña.
Rev Esp Cardiol. 1998 May;51(5):396-401. doi: 10.1016/s0300-8932(98)74764-5.
The marked increase in cocaine consumption observed in recent decades, has led to the identification of previously unknown multiple medical problems. Cardiovascular complications related to cocaine abuse include myocardial ischemia and infarction, myocarditis, cardiomyopathy, rhythm disturbances and sudden death, endocarditis, pneumopericardium and left ventricular hypertrophy. Although the mechanisms involved in cocaine-related cardiac diseases are multiple, many cardiac complications in these patients are caused in part or totally by an increase in adrenergic activity due to the blockade of catecholamine reuptake induced by the drug.
近几十年来观察到的可卡因消费量显著增加，已导致发现了以前未知的多种医学问题。与可卡因滥用相关的心血管并发症包括心肌缺血和梗死、心肌炎、心肌病、心律失常和猝死、心内膜炎、纵隔积气和左心室肥厚。尽管可卡因相关心脏疾病涉及的机制多种多样，但这些患者的许多心脏并发症部分或完全是由药物诱导的儿茶酚胺再摄取受阻导致的肾上腺素能活性增加引起的。
