Danilkov A P, Ivashchenko V V, Kirpatovskiĭ V I, Kudriavtsev Iu V, Lavrinova L N
Urol Nefrol (Mosk). 1998 May-Jun(3):25-7.
The action of indirect electrochemical blood oxidation with 0.06% solution of sodium hypochlorite on kidney and urinary inflammation was studied in experiments on 60 non-inbred rat females of 200-250 g body weight. The animals were intravesically infected through the catheter with E. coli and Ps. aeruginosa. 3 days later, after histological verification of acute pyelonephritis, ureteritis, cystitis, the animals were injected intraperitoneally 1.0 and 2.0 ml daily of sodium hypochlorite solution (control animals) or 0.89% solution of sodium chloride. Though no reliable decrease of the bacterial contamination was achieved, histologically, there was a marked reduction in morphological signs of the inflammation in the kidneys, ureter and urinary bladder on the first day after beginning of electrochemical blood oxidation with solution of sodium hypochlorite in experimental groups. In experimental group rats morphological signs of urinary and renal inflammation for both infections disappeared on days 7 and 10, respectively. In the control animals morphological signs of the inflammation remained after 10 days. Moreover, purulent inflammation was registered in the controls infected with Ps. aeruginosa.
在对60只体重200 - 250克的非近交雌性大鼠进行的实验中，研究了用0.06%次氯酸钠溶液进行间接电化学血液氧化对肾脏和泌尿系统炎症的作用。通过导管将大肠杆菌和铜绿假单胞菌经膀胱内感染动物。3天后，在对急性肾盂肾炎、输尿管炎、膀胱炎进行组织学验证后，给动物腹腔注射，对照组动物每天注射1.0和2.0毫升次氯酸钠溶液，或0.89%氯化钠溶液。尽管细菌污染没有可靠地减少，但在实验组中，从开始用次氯酸钠溶液进行电化学血液氧化后的第一天起，组织学上肾脏、输尿管和膀胱的炎症形态学体征有明显减轻。在实验组大鼠中，两种感染的泌尿系统和肾脏炎症形态学体征分别在第7天和第10天消失。在对照动物中，10天后炎症形态学体征仍然存在。此外，感染铜绿假单胞菌的对照组出现了化脓性炎症。
