Poljak M, Tomazic J, Seme K, Maticic M, Vidmar L
Slovenian AIDS Reference Centre, Medical Faculty of Ljubljana, Slovenia.
Acta Virol. 1998 Feb;42(1):23-6.
A 32 bp deletion in the CCR5 gene designated CCR5 delta 32 has been identified recently as the cellular basis for resistance to human immunodeficiency virus type 1 (HIV-1) in some individuals which remained non-infected despite a repeated exposure to this virus. The prevalence of this deletion was examined by polymerase chain reaction (PCR) on 51 HIV-1-infected and 385 non-infected individuals from all parts of Slovenia. 84.4% of the the HIV-1-infected and 83.2% of the non-infected individuals were homozygous for wild type CCR5, and 19.6% and 16.3%, respectively, were heterozygous. No homozygous mutant genotype was observed among the HIV-1-infected patients. Of the non-infected individuals, 2 women (0.5%) were found to harbour the CCR5 delta 32/CCR5 delta 32 genotype only, which is, to the best of our knowledge, the lowest prevalence of this particular genotype found among Caucasians to date.
CCR5基因中一个32bp的缺失，即CCR5 delta 32，最近被确定为某些个体对1型人类免疫缺陷病毒（HIV-1）具有抗性的细胞基础，这些个体尽管反复接触该病毒仍未被感染。通过聚合酶链反应（PCR）对来自斯洛文尼亚各地的51名HIV-1感染者和385名未感染者进行检测，以检查该缺失的流行情况。84.4%的HIV-1感染者和83.2%的未感染者CCR5野生型为纯合子，杂合子分别占19.6%和16.3%。在HIV-1感染患者中未观察到纯合突变基因型。在未感染个体中，发现2名女性（0.5%）仅携带CCR5 delta 32/CCR5 delta 32基因型，据我们所知，这是迄今为止在高加索人群中发现的该特定基因型的最低流行率。
