Emmrich P, Friedrich T, Dalitz H
Institut für Pathologie, Universität Leipzig.
Ann Anat. 1998 Jun;180(3):203-9.
We investigated the morphologically distinct forms of inflammatory infiltration of the placenta both histologically and immunohistologically (n = 24). Our material included cases of membraneous inflammation (chorioamnionitis), inflammatory infiltration of arteries in the chorionic membrane, basal and intervillous placentitis. NACE staining was used to detect myeloid cells and monoclonal antibodies (LCA, CD3, CD8, CD20, CD68). To detect lymphoid and macrophageal cells we also measured the proliferation activity with MiB 1. In cases of chorioamnionitis and subchorial demarcation and in the arteries of the chorionic membranes the main inflammatory cell is the myeloid cell (most often the mature neutrophil granulocyte). T-lymphocytes were only occasionally found. In cases of intervillous placentitis, on the other hand, lymphocytic infiltration predominates, consisting of T-lymphocytes which are mostly CD8 negative, and some monocytes and macrophages. Basal inflammation in the demarcation zone was characterized by T-lymphocytes. We interpret this as indicating basal demarcation. According to our histological and immunohistological observations, "asphyxial infiltrates" are abortive forms of a placental (bacteriological) inflammation, possibly infective in origin. We do not consider asphyxial infiltration to be a separate entity with its own causal pathogenesis.
我们通过组织学和免疫组织学方法（n = 24）研究了胎盘炎症浸润的形态学不同形式。我们的材料包括膜性炎症（绒毛膜羊膜炎）、绒毛膜动脉炎症浸润、基底和绒毛间隙胎盘炎的病例。采用萘酚AS-D氯乙酸酯酶（NACE）染色检测髓样细胞，并使用单克隆抗体（LCA、CD3、CD8、CD20、CD68）。为了检测淋巴细胞和巨噬细胞，我们还用MiB 1测量了增殖活性。在绒毛膜羊膜炎和绒毛膜下分界处以及绒毛膜动脉中，主要的炎症细胞是髓样细胞（最常见的是成熟的中性粒细胞）。仅偶尔发现T淋巴细胞。另一方面，在绒毛间隙胎盘炎病例中，淋巴细胞浸润占主导，由大多为CD8阴性的T淋巴细胞以及一些单核细胞和巨噬细胞组成。分界区的基底炎症以T淋巴细胞为特征。我们将此解释为表明基底分界。根据我们的组织学和免疫组织学观察，“窒息性浸润”是胎盘（细菌性）炎症的流产形式，可能起源于感染。我们不认为窒息性浸润是具有自身因果发病机制的独立实体。
