Ristamäki R, Joensuu H, Hagberg H, Kalkner K M, Jalkanen S
National Public Health Institute, Department of Oncology, University of Turku, Finland.
Int J Cancer. 1998 Jun 19;79(3):221-5. doi: 10.1002/(sici)1097-0215(19980619)79:3<221::aid-ijc2>3.0.co;2-r.
Soluble isoforms of various adhesion molecules have recently been observed in the blood circulation, but the physiological effects of such molecules remain unsettled. Our earlier results indicate that soluble CD44 can be detected in sera of healthy individuals and that significantly higher levels of serum CD44 (s-CD44) can be found in lymphoma patients. The serum level of the standard form of CD44 parallels the clinical treatment response in patients with lymphoma. In the present study, we have investigated the clinical significance of s-CD44 in non-Hodgkin's lymphoma measured at the time of the diagnosis. S-CD44 was measured from the sera of 123 patients with non-Hodgkin's lymphoma by dot blotting high levels of s-CD44 were associated with high serum levels of lactate dehydrogenase and thymidine kinase, high histological grade of malignancy and poor overall survival. However, s-CD44 level did not have independent prognostic value in a multivariate analysis. In conclusion, a high s-CD44 level at the time of diagnosis was associated with poor survival and several other adverse prognostic factors. Our previous and present studies taken together suggest that measurement of s-CD44 is a valuable tool to monitor treatment response in lymphoma patients. However, it may not be an improved prognostic marker.
最近在血液循环中观察到了各种粘附分子的可溶性异构体，但此类分子的生理效应仍未明确。我们早期的研究结果表明，在健康个体的血清中可检测到可溶性CD44，并且在淋巴瘤患者中血清CD44（s-CD44）水平明显更高。CD44标准形式的血清水平与淋巴瘤患者的临床治疗反应平行。在本研究中，我们调查了诊断时所测s-CD44在非霍奇金淋巴瘤中的临床意义。通过斑点印迹法检测了123例非霍奇金淋巴瘤患者血清中的s-CD44，高水平的s-CD44与高血清乳酸脱氢酶和胸苷激酶水平、高组织学恶性程度以及较差的总生存率相关。然而，在多变量分析中s-CD44水平没有独立的预后价值。总之，诊断时s-CD44水平高与生存率低以及其他几个不良预后因素相关。我们之前和现在的研究共同表明，检测s-CD44是监测淋巴瘤患者治疗反应的一个有价值的工具。然而，它可能不是一个更好的预后标志物。
