Reinhold D, Vetter R W, Mnich K, Bühling F, Lendeckel U, Born I, Faust J, Neubert K, Gollnick H, Ansorge S
Institute of Experimental Internal Medicine, Department of Internal Medicine, Otto-von-Guericke-University Magdeburg, Germany.
FEBS Lett. 1998 May 22;428(1-2):100-4. doi: 10.1016/s0014-5793(98)00502-x.
Various studies have shown that the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26), expressed on T, NK, and B cells in the human immune system, is involved in the regulation of DNA synthesis and cytokine production. Here, we clearly demonstrate that this enzyme is highly expressed also on human epidermal foreskin and split-skin keratinocytes and that the specific DP IV inhibitors Lys[Z(NO2)]-thiazolidide, Lys[Z(NO2)]-pyrrolidide inhibit the enzymatic activity as well as the DNA synthesis of these cells. These data demonstrate that CD26 plays a role also in regulation of DNA synthesis of epidermal keratinocytes and that the enzymatic activity is required for mediating these effects.
多项研究表明，人免疫系统中T细胞、NK细胞和B细胞上表达的膜外切酶二肽基肽酶IV（DP IV，CD26）参与DNA合成和细胞因子产生的调节。在此，我们明确证明该酶在人表皮包皮和分层皮肤角质形成细胞上也高度表达，并且特异性DP IV抑制剂Lys[Z(NO2)]-噻唑烷二酮、Lys[Z(NO2)]-吡咯烷二酮可抑制这些细胞的酶活性以及DNA合成。这些数据表明，CD26在表皮角质形成细胞DNA合成的调节中也发挥作用，并且酶活性是介导这些效应所必需的。
