Nagafuji K, Eto T, Hayashi S, Oshima K, Maeda Y, Gondo H, Inamura T, Niho Y
Department of Hematology, Hara Sanshin General Hospital, Fukuoka, Japan.
Bone Marrow Transplant. 1998 Jun;21(11):1155-8. doi: 10.1038/sj.bmt.1701205.
EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 10(6)CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.
