Parks E, Lukacs N W, Strieter R M, Kunkel S L
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109-0602, USA.
Pathobiology. 1998;66(2):64-70. doi: 10.1159/000027998.
Endothelial cells play a critical role in the recruitment of immune cells due to their position at the interface between circulating cells and the inflamed tissue. In this study, human umbilical vein endothelial cells (HUVECs) and human monocytes were used to investigate the role of various cytokines in the regulation of C-C and C-X-C chemokine production. We have demonstrated that IL-4 and IL-10 negatively affect certain monocyte-derived chemokines, while not suppressing HUVEC-derived chemokines. The differential induction of chemokines by selected cytokines may help delineate the type(s) of leukocytes that are recruited during certain phases of an inflammatory response.
内皮细胞因其处于循环细胞与炎症组织之间的界面位置，在免疫细胞募集中发挥关键作用。在本研究中，使用人脐静脉内皮细胞（HUVECs）和人单核细胞来研究各种细胞因子在调节C-C和C-X-C趋化因子产生中的作用。我们已经证明，IL-4和IL-10对某些单核细胞衍生的趋化因子有负面影响，而不抑制HUVEC衍生的趋化因子。特定细胞因子对趋化因子的差异诱导可能有助于描绘在炎症反应的某些阶段募集的白细胞类型。
