Kodsi B E, Wickremesinghe C, Kozinn P J, Iswara K, Goldberg P K
Gastroenterology. 1976 Nov;71(5):715-9.
A prospective study of candida esophagitis was undertaken to determine the spectrum of this disease in a general hospital. During 1 year, in 370 consecutive endoscopies, 27 patients with Candida esophagitis were detected. The diagnosis was established by finding white plaques on endoscopy, yeast organisms on microscopic examination of a direct smear from the plaques, and a serum agglutinin titer of at least 1:160. Of these 27 patients, 14 had esophageal symptoms. Twelve patients were reendoscoped after nystatin or nystatin and flucytosine therapy. Nine patients showed absence of lesions, a negative smear, and disappearance of symptoms. Control patients had no plaques on endoscopy, no yeast organisms on microscopical examination of esophageal brushings, and a positive titer in 4 to 17% of cases. A minimal agglutinin titer of 1:160 was found in 4 to 12% of two additional groups on controls. Absence of titer precluded a diagnosis of Candida esophagitis.
为确定综合医院中念珠菌食管炎的疾病谱，开展了一项关于念珠菌食管炎的前瞻性研究。在1年时间里，在连续370例内镜检查中，检测到27例念珠菌食管炎患者。通过在内镜检查中发现白色斑块、对斑块直接涂片进行显微镜检查发现酵母样菌以及血清凝集素滴度至少为1:160来确立诊断。在这27例患者中，14例有食管症状。12例患者在接受制霉菌素或制霉菌素与氟胞嘧啶治疗后再次接受内镜检查。9例患者病变消失、涂片阴性且症状消失。对照患者内镜检查无斑块，食管刷检显微镜检查无酵母样菌，4%至17%的病例凝集素滴度呈阳性。在另外两组对照中，4%至12%的病例凝集素滴度最低为1:160。无滴度可排除念珠菌食管炎的诊断。
