Osterlund M K, Hurd Y L
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden.
Brain Res Mol Brain Res. 1998 Mar 30;55(1):169-72. doi: 10.1016/s0169-328x(98)00018-7.
In situ hybridization histochemistry was used to investigate acute estrogen effects on serotonin 5HT1A receptor mRNA levels in limbic-related brain areas in the female ovariectomized rat. Acute administration of 17 beta-estradiol (10 micrograms) decreased 5HT1A receptor mRNA expression levels within the medial amygdala (after 2 and 24 h), piriform cortex (after 2 and 24 h), and perirhinal cortex (after 24 h). No changes in 5HT1A mRNA levels were observed in hippocampus or retrosplenial cortex. The findings suggest specific regional effects of estrogen on 5HT functions mediated through regulation of the 5HT1A gene.
采用原位杂交组织化学技术，研究急性雌激素对去卵巢雌性大鼠边缘系统相关脑区5-羟色胺5HT1A受体mRNA水平的影响。急性给予17β-雌二醇（10微克）可降低杏仁核内侧（2小时和24小时后）、梨状皮质（2小时和24小时后）和嗅周皮质（24小时后）内5HT1A受体mRNA的表达水平。在海马体或压后皮质中未观察到5HT1A mRNA水平的变化。这些发现表明雌激素通过调控5HT1A基因对5-羟色胺功能具有特定的区域效应。
