College of Food Science, South China Agricultural University, Guangzhou, 510642, China.
Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou, 510642, China.
Environ Sci Pollut Res Int. 2017 Mar;24(9):8279-8286. doi: 10.1007/s11356-017-8487-6. Epub 2017 Feb 3.
Nonylphenol (NP) and octylphenol (OP) are priority environmental contaminants that have a potential role as endocrine disruptors. They can be biomagnified in the food chain and pose an estrogenic health risk to human health. A 28-day oral toxicity study was performed to observe the impact of single and combined exposure to NP and OP on 5-HT transporter (SERT) as well as 5-HT receptor. Results showed that the 5-HT levels in rat plasma increased with exposure to middle-dose and high-dose NP, to high-dose OP, and to low, middle, and high doses of combined NP and OP (P < 0.05), while the 5-HT levels in rat platelets increased when exposed to NP/OP or combined NP and OP of middle or high dose (P < 0.05). The expression levels of SERT in rat platelets decreased when exposed to high-dose NP/OP or high dose of combined NP and OP (P < 0.05). Meanwhile, the expression levels of 5-HT in rat platelets decreased when exposed to high-dose NP/OP as well as combined NP and OP (P < 0.05). These findings suggested that exposure to NP and OP could influence the metabolic network of 5-hydroxytryptamine via transportation and receptor binding pathways.
壬基酚（NP）和辛基酚（OP）是优先环境污染物，具有作为内分泌干扰物的潜在作用。它们可以在食物链中生物放大，并对人类健康构成雌激素健康风险。进行了 28 天的口服毒性研究，以观察单一和联合暴露于 NP 和 OP 对 5-羟色胺转运体（SERT）和 5-羟色胺受体的影响。结果表明，随着中剂量和高剂量 NP、高剂量 OP 以及低、中、高剂量 NP 和 OP 的暴露，大鼠血浆中的 5-HT 水平升高（P<0.05），而当暴露于 NP/OP 或中剂量或高剂量的 NP 和 OP 联合时，大鼠血小板中的 5-HT 水平升高（P<0.05）。当暴露于高剂量 NP/OP 或高剂量 NP 和 OP 联合时，大鼠血小板中 SERT 的表达水平降低（P<0.05）。同时，当暴露于高剂量 NP/OP 以及 NP 和 OP 联合时，大鼠血小板中的 5-HT 表达水平降低（P<0.05）。这些发现表明，NP 和 OP 的暴露可能通过运输和受体结合途径影响 5-羟色胺的代谢网络。
