Capuano V, Lamaida N, Mazzotta G, Scotto di Quacquaro G
Reparto di Cardiologia Ospedale di Mercato San Severino (SA), Genova.
G Ital Cardiol. 1998 May;28(5):530-5.
Several epidemiological studies have shown a relation between white blood cell (WBC) count in peripheral blood samples and other cardiovascular risk factors. Such associations have also been described in patients affected by dyslipidemia. On the other hand, no data are available in patients with systemic hypertension.
In a southern Italian population of hypertensive patients, in order to assess the relation between WBC count and other risk factors for coronary artery disease; in addition, to evaluate if a high WBC count can identify subgroups of hypertensives with a higher risk profile for atherosclerosis.
We evaluated 147 consecutive patients (44 males, mean age 49 +/- 11 years) with a minimum 2-year history of systemic hypertension in the absence of ischemic heart disease and cerebrovascular disease. Among risk factors, we considered: hypercholesterolemia, hypertriglyceridemia, hyperglycemia and obesity.
WBC count was significantly higher in patients with 2 or more risk factors (7.092 +/- 1034 cells/dl than in hypertensives without risk factors (5.902 +/- 1167, p < 0.0001). WBC count was significantly associated with hyperglycemia (p < 0.001), number of cigarettes smoked daily (p < 0.004), fibrinogen plasma levels (p < 0.008) and azotemia (p < 0.009). Multivariate analysis has shown a positive significant and independent relation between WBC count and both hyperglycemia and number of cigarettes.
These results emphasize that, among hypertensives, subgroups with a higher WBC count also have a higher risk profile for atherogenesis. The relation between WBC and some risk factors is confirmed by our data in a population of patients affected with systemic hypertension.
多项流行病学研究表明，外周血样本中的白细胞（WBC）计数与其他心血管危险因素之间存在关联。血脂异常患者中也有此类关联的描述。另一方面，关于系统性高血压患者的数据尚无可用信息。
在意大利南部的高血压患者群体中，评估白细胞计数与冠状动脉疾病其他危险因素之间的关系；此外，评估高白细胞计数是否能识别出动脉粥样硬化风险更高的高血压亚组。
我们评估了147例连续的患者（44例男性，平均年龄49±11岁），这些患者有至少2年的系统性高血压病史，且无缺血性心脏病和脑血管疾病。在危险因素方面，我们考虑了：高胆固醇血症、高甘油三酯血症、高血糖和肥胖。
有2种或更多危险因素的患者白细胞计数（7.092±1034个/微升）显著高于无危险因素的高血压患者（5.902±1167，p<0.0001）。白细胞计数与高血糖（p<0.001）、每日吸烟量（p<0.004）、血浆纤维蛋白原水平（p<0.008）和氮质血症（p<0.009）显著相关。多变量分析显示白细胞计数与高血糖和吸烟量之间存在显著的正相关且独立关系。
这些结果强调，在高血压患者中，白细胞计数较高的亚组动脉粥样硬化发生风险也更高。我们在系统性高血压患者群体中的数据证实了白细胞与一些危险因素之间的关系。
