Milner R J, Dormehl I, Louw W K, Croft S
Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
J S Afr Vet Assoc. 1998 Mar;69(1):12-7. doi: 10.4102/jsava.v69i1.802.
Nine dogs with primary bone tumours were treated with Samarium-153-EDTMP (Sm-153-EDTMP). Conventional treatment protocols were precluded by the size of the dogs and the owners' refusal of limb amputation. All the tumours were of the appendicular skeleton; 4 were confirmed osteosarcomas. The other 5 tumours were radiologically suspect for osteosarcoma. Bone scans were performed on all dogs using Technetium-99m-methylene diphosphonate (Tc-99m-MDP) before administration of Sm-153-EDTMP. Regions of interest were identified over the contralateral limb at the same site as the tumour and counts per pixel were recorded for the tumour and contralateral limb and expressed as a ratio. The dogs were given 1 injection of 37 MBq/kg (1 mCi/kg) of Sm-153-EDTMP intravenously. Thoracic and primary tumour site radiographs were taken at monthly or 2-monthly intervals to monitor progression of the primary tumour and search for evidence of metastasis. Two dogs showed no response to treatment, with an increase in bone pain, and were euthanased within 1 month. In 1 dog, a tumour of the scapula underwent complete involution and the dog is considered free of disease at 20 months post Sm-153-EDTMP treatment. The overall tumourcidal effect of a single dose of Sm-153-EDTMP on primary bone tumours was difficult to evaluate in this group of dogs, as, with one exception, all the primary tumours progressed over time and the dogs were euthanased. Pain control, for which Sm-155-EDTMP is used in man, was not evident, except in the dog that responded completely to treatment.
9只患有原发性骨肿瘤的犬接受了钐-153-乙二胺四甲基膦酸（Sm-153-EDTMP）治疗。由于犬的体型以及主人拒绝截肢，所以未采用传统治疗方案。所有肿瘤均位于四肢骨骼；4例确诊为骨肉瘤。另外5例肿瘤在放射学上怀疑为骨肉瘤。在给予Sm-153-EDTMP之前，所有犬均使用锝-99m-亚甲基二膦酸盐（Tc-99m-MDP）进行骨扫描。在对侧肢体与肿瘤相同部位确定感兴趣区域，并记录肿瘤和对侧肢体的每像素计数，并表示为比值。给犬静脉注射1次37 MBq/kg（1 mCi/kg）的Sm-153-EDTMP。每隔1个月或2个月拍摄胸部和原发性肿瘤部位的X光片，以监测原发性肿瘤的进展并寻找转移证据。2只犬对治疗无反应，骨痛加重，在1个月内实施安乐死。1只犬肩胛骨的肿瘤完全消退，在接受Sm-153-EDTMP治疗后20个月，该犬被认为无病。在这组犬中，单剂量Sm-153-EDTMP对原发性骨肿瘤的总体杀瘤效果难以评估，因为除1例例外，所有原发性肿瘤均随时间进展，犬被实施安乐死。除了对治疗完全有反应的那只犬外，使用Sm-155-EDTMP用于人类的疼痛控制并不明显。
