van Eijck C H, Kwekkeboom D J, Krenning E P
Department of Surgery and Nuclear Medicine University Hospital, Rotterdam, The Netherlands.
Q J Nucl Med. 1998 Mar;42(1):18-25.
The study of breast carcinogenesis is complicated by the heterogeneity of the disease. One way of simplifying is to subdivide these tumors into clinically relevant subgroups. There are indications that breast carcinomas, of which some express the somatostatin receptor (SS-R), can be divided this way. Expression of somatostatin receptors (SS-R's) in human primary breast cancer has a very high incidence. This can be demonstrated by in vitro autoradiography and in vivo by somatostatin receptor scintigraphy. However the clinical significance of somatostatin receptor expression in human breast cancer needs to be investigated. In this review article we summarize the current understanding of the functional role of somatostatin receptors in human breast cancer. Their relationship with neuroendocrine differentiation of the cancers and genetic and patient characteristics, the role of in vivo SS-R's visualization, and the possible medical and radiotherapeutic implications of these findings are discussed.
乳腺癌发生的研究因该疾病的异质性而变得复杂。简化研究的一种方法是将这些肿瘤细分为临床相关的亚组。有迹象表明，其中一些表达生长抑素受体（SS-R）的乳腺癌可以通过这种方式进行划分。生长抑素受体（SS-R）在人类原发性乳腺癌中的表达发生率非常高。这可以通过体外放射自显影和体内生长抑素受体闪烁显像来证明。然而，生长抑素受体在人类乳腺癌中表达的临床意义有待研究。在这篇综述文章中，我们总结了目前对生长抑素受体在人类乳腺癌中功能作用的理解。讨论了它们与癌症神经内分泌分化以及基因和患者特征的关系、体内SS-R可视化的作用，以及这些发现可能的医学和放射治疗意义。
