补体系统的非典型丝氨酸蛋白酶。 - Suppr

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超能文献

The atypical serine proteases of the complement system.

作者信息

Arlaud G J, Volanakis J E, Thielens N M, Narayana S V, Rossi V, Xu Y

机构信息

Laboratoire d'Enzymologie Moléculaire, Institut de Biologie Structurale Jean-Pierre Ebel, Grenoble, France.

出版信息

Adv Immunol. 1998;69:249-307.

PMID:9646846

Abstract

摘要

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The atypical serine proteases of the complement system.补体系统的非典型丝氨酸蛋白酶。

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Evolutionary conserved rigid module-domain interactions can be detected at the sequence level: the examples of complement and blood coagulation proteases.在序列水平上可以检测到进化保守的刚性模块-结构域相互作用：补体和血液凝固蛋白酶的例子。

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The macromolecular assembly of pathogen-recognition receptors is impelled by serine proteases, via their complement control protein modules.病原体识别受体的大分子组装由丝氨酸蛋白酶通过其补体控制蛋白模块推动。

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Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures.补体系统中具有九个相关晶体结构的假定丝氨酸蛋白酶折叠的蛋白质的鉴定。

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A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease.果蝇中用于确定背腹模式的一个基因似乎编码一种丝氨酸蛋白酶。

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The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex.补体蛋白酶C1r的酶原催化结构域的晶体结构表明，需要一种破坏性的机械应力来触发C1复合物的激活。

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