Lazarchick J, Hopkins M
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston 29425, USA.
Ann Clin Lab Sci. 1998 May-Jun;28(3):150-2.
Absent or diminished HLA-Dr antigen representation on the cell surface of both normal and leukemic promyelocytes is a hallmark of this stage of myeloid maturation. In order to document the specificity of this finding for acute promyelocytic leukemia, flow cytometric analysis of leukemic blasts was utilized on 36 cases of acute non-lymphocytic leukemia. All 15 of the promyelocytic leukemias (FAB-M3) studied showed absent or markedly decreased HLA-Dr antigen on their cell surface. However, the majority of cases (21) in which this finding was noted were other than promyelocytic leukemias and included all FAB subtypes, most particularly FAB-M2, i.e., myeloblastic leukemia with maturation. It is concluded that absent to decreased HLA-Dr antigen representation on leukemic blasts lacks specificity and can be seen in all acute myeloid/monocytic leukemic subtypes.
正常和白血病早幼粒细胞细胞表面HLA-Dr抗原表达缺失或减少是髓系成熟这一阶段的一个标志。为了证明这一发现对急性早幼粒细胞白血病的特异性，对36例急性非淋巴细胞白血病患者的白血病原始细胞进行了流式细胞术分析。所研究的15例早幼粒细胞白血病（FAB-M3）均显示其细胞表面HLA-Dr抗原表达缺失或显著降低。然而，发现这一现象的大多数病例（21例）并非早幼粒细胞白血病，包括所有FAB亚型，最常见的是FAB-M2，即伴有成熟的粒细胞白血病。得出的结论是，白血病原始细胞表面HLA-Dr抗原表达缺失至减少缺乏特异性，可见于所有急性髓系/单核细胞白血病亚型。
