Mazurek M F, Savedia S M, Bobba R S, Garside S, Rosebush P I
Department of Medicine (Neurology), McMaster University Medical Centre, Hamilton, Ontario, Canada.
J Neurol Neurosurg Psychiatry. 1998 Jun;64(6):799-801. doi: 10.1136/jnnp.64.6.799.
A 37 year woman developed neuroleptic induced parkinsonism that persisted long after the drug had been discontinued. This prompted a study of the effect of an eight week course of haloperidol (HAL) followed by two week withdrawal, on dopaminergic neurons of the substantia nigra in rats. Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour. Neuroleptic drug induced downregulation of nigral dopaminergic neurons may help to explain the persistent parkinsonism found in many patients after withdrawal of medication.
一名37岁女性出现了抗精神病药物诱发的帕金森症，在停药后仍持续存在。这促使开展了一项研究，观察给予大鼠为期八周的氟哌啶醇（HAL）治疗，随后停药两周，对黑质多巴胺能神经元的影响。接受HAL治疗的动物黑质中酪氨酸羟化酶（TH）免疫反应性神经元显著损失32%-46%，TH染色的树突分支收缩20%。抗精神病药物诱发的黑质多巴胺能神经元下调可能有助于解释许多患者停药后仍存在的持续性帕金森症。
