Hull M L, Livesey J H, Evans J J, Benny P S
Department of Obstetrics and Gynaecology, Christchurch School of Medicine, New Zealand.
Hum Reprod. 1998 May;13(5):1139-43. doi: 10.1093/humrep/13.5.1139.
Parenteral administration of follicle stimulating hormone (FSH) has been shown to lower luteinizing hormone (LH) concentrations in women undergoing ovulation induction. This study was designed to explore the physiological mechanism of this effect. Seven healthy women were recruited into a double-blind placebo-controlled study. LH secretion, after the administration of variable i.v. boluses (37.5, 75 and 150 IU) of recombinant FSH (Gonal-F), was evaluated. LH was measured at 10 min intervals for 2 h before and 4 h after the FSH/placebo infusion. LH pulse frequency and amplitude were evaluated and there was no significant difference between control and trial cycles for each subject. A linear regression analysis revealed that in the group receiving 150 IU FSH, the mean plasma LH concentration decreased significantly due to a reduction tonic LH secretion. This could be a result of the suppression of secretion or an alteration of clearance. This decrease was not seen in the other dosage groups, revealing that above a dosage threshold, FSH reduced non-pulsatile LH secretion. Therefore the effect of FSH in this study exposed the likely presence of two components of LH concentration: an FSH-sensitive, non-pulsatile tonic secretion and a gonadotrophin-releasing hormone-stimulated, pulsatile release that is unaffected by FSH. Although an indirect effect involving ovarian regulation is not excluded, the rapidity of the effect suggests that FSH acts directly on the pituitary gland.
已证实，对接受排卵诱导的女性进行促卵泡激素（FSH）的肠胃外给药可降低促黄体生成素（LH）的浓度。本研究旨在探究这一效应的生理机制。七名健康女性被纳入一项双盲安慰剂对照研究。评估了静脉注射不同剂量（37.5、75和150国际单位）的重组FSH（果纳芬）后LH的分泌情况。在FSH/安慰剂输注前2小时和输注后4小时，每隔10分钟测量一次LH。评估了LH的脉冲频率和幅度，每个受试者的对照周期和试验周期之间无显著差异。线性回归分析显示，在接受150国际单位FSH的组中，由于LH的紧张性分泌减少，平均血浆LH浓度显著降低。这可能是分泌抑制或清除改变的结果。在其他剂量组中未观察到这种降低，这表明超过剂量阈值时，FSH会减少非脉冲性LH分泌。因此，本研究中FSH的作用揭示了LH浓度可能存在的两个组成部分：对FSH敏感的非脉冲性紧张性分泌以及不受FSH影响的促性腺激素释放激素刺激的脉冲性释放。尽管不排除涉及卵巢调节的间接作用，但这种作用的快速性表明FSH直接作用于垂体。
