Nakayama H, Miyazaki E, Hiroi M, Kiyoku H, Naruse K, Enzan H
First Department of Pathology, Kochi Medical School, Japan.
Pathol Int. 1998 Apr;48(4):245-53. doi: 10.1111/j.1440-1827.1998.tb03902.x.
An immunohistochemical study of nine cases of chondroid syringomas/mixed tumors of the skin was performed to elucidate the nature of the so-called neoplastic myoepithelial cells (NMEC) in tumor tissues. These nine tumors contained NMEC of considerable variability in number from one tumor to another. These NMEC were classified into three types: (i) hyaline cells (plasmacytoid cells); (ii) spindle NMEC; and (iii) polyhedral cells. They showed different immunostaining patterns, as the following describes. Cytokeratin 14 was positive in most of the spindle NMEC and a large number of the polyhedral cells, and in a small number of the hyaline cells. Concerning low molecular weight cytokeratins, most of the hyaline cells showed immunoreactivity, whereas they were negative in many of the spindle NMEC and were expressed only in a small number of the polyhedral cells. alpha-Smooth muscle actin and muscle-specific actin were positive in the spindle NMEC but negative in any of the hyaline cells and polyhedral cells. These findings strongly indicate that the hyaline cells and the spindle NMEC are of the simple epithelial and myoepithelial types, respectively. The findings also suggest that the polyhedral cells show differentiation toward basal cells of the sweat gland dermal ducts or myoepithelial cells.
对9例皮肤软骨样汗腺腺瘤/混合瘤进行了免疫组织化学研究，以阐明肿瘤组织中所谓的肿瘤性肌上皮细胞（NMEC）的性质。这9个肿瘤中所含的NMEC数量在不同肿瘤之间差异很大。这些NMEC分为三种类型：（i）透明细胞（浆细胞样细胞）；（ii）梭形NMEC；（iii）多面体细胞。如下所述，它们呈现出不同的免疫染色模式。细胞角蛋白14在大多数梭形NMEC和大量多面体细胞中呈阳性，在少数透明细胞中也呈阳性。关于低分子量细胞角蛋白，大多数透明细胞显示免疫反应性，而许多梭形NMEC呈阴性，仅在少数多面体细胞中表达。α-平滑肌肌动蛋白和肌肉特异性肌动蛋白在梭形NMEC中呈阳性，但在任何透明细胞和多面体细胞中均呈阴性。这些发现强烈表明，透明细胞和梭形NMEC分别属于单纯上皮型和肌上皮型。这些发现还表明，多面体细胞表现出向汗腺真皮导管基底细胞或肌上皮细胞的分化。
