Translocation (10;11)(p13;q13) and MLL gene rearrangement in a case of AML (M5a) with aggressive leukemia cutis.
作者信息
Kubonishi I, Seto M, Murata N, Kamioka M, Taguchi H, Miyoshi I
机构信息
Department of Medicine, Kochi Medical School, Japan.
出版信息
Cancer Genet Cytogenet. 1998 Jul 1;104(1):28-31. doi: 10.1016/s0165-4608(97)00414-7.
PMID:9648554
Abstract
A male patient with a secondary acute monocytic leukemia whose leukemia cells had a t(10;11)(p13;q13) chromosomal abnormality is described. Gene analysis disclosed that the patient's leukemia cells had MLL gene rearrangement. His leukemia cells responded poorly to chemotherapy, and the patient developed an unusual aggressive leukemia cutis. A t(10;11)(p13;q13) chromosomal abnormality that expresses MLL gene rearrangement has not been reported previously in secondary leukemia.
摘要
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