Ayala A G, Ro J Y
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Semin Urol Oncol. 1998 May;16(2):72-81.
Testicular germ cell neoplasms affect young men in the prime of life. Although the overwhelming majority are malignant, they are curable. In addition to the stage of the disease and the presence of serum markers, there are important pathological changes that have clinical significance. These include (1) the cell type, (2) the amount of the component, and (3) the presence or absence of vascular invasion. Pure embryonal carcinoma or embryonal carcinoma in excess of 80% in a mixed tumor and vascular/lymphatic invasion are high-risk factors as they are predictors of relapse. These factors should be recognized by the pathologist and should be taken into account by the oncologist when selecting the management of a patient with a germ cell tumor of the testis.
睾丸生殖细胞肿瘤影响处于人生黄金时期的年轻男性。尽管绝大多数是恶性的，但它们是可治愈的。除了疾病分期和血清标志物的存在外，还有一些具有临床意义的重要病理变化。这些包括：（1）细胞类型；（2）成分的数量；（3）是否存在血管侵犯。纯胚胎癌或混合肿瘤中胚胎癌超过80%以及血管/淋巴管侵犯都是高危因素，因为它们是复发的预测指标。病理学家应认识到这些因素，肿瘤学家在选择睾丸生殖细胞肿瘤患者的治疗方案时也应予以考虑。
