Oshima K, Matsumoto K, Tsuda T, Shibata K, Hayashi M
Prostaglandins. 1978 Mar;15(3):473-83. doi: 10.1016/0090-6980(78)90131-4.
The smooth muscle stimulating activity of a new PGE1 analog, 16, 16-dimethyl- trans delta2 -PGE1 methyl ester (ONO-802) was evaluated by simultaneously recording the EMG of the uterus and intestines, along with urinary bladder pressure, and blood pressure in pregnant and non-pregnant Japanese monkeys (Macaca fuscata fuscata). Single intravenous injections of ONO-802 in increasing dosages (0.2-5 microgram/kg) were found to be 50-100 times or more effective in inducing uterine contraction than PGF2alpha and PGE1. A mild, transient gastrointestinal muscle stimulating activity was observed, but change in urinary bladder pressure and blood pressure was not evident. ONO-802 induced uterine contractions in the pregnant animals were 10 times greater than in the non-pregnant animals. These results suggest that ONO-802 may be a suitable clinical prostaglandin for use in therapeutic abortion.
通过同时记录怀孕和未怀孕的日本猕猴（食蟹猴指名亚种）子宫和肠道的肌电图、膀胱压力及血压，对一种新型前列腺素E1类似物16,16 - 二甲基 - 反式δ2 - 前列腺素E1甲酯（ONO - 802）的平滑肌刺激活性进行了评估。发现以递增剂量（0.2 - 5微克/千克）单次静脉注射ONO - 802，诱导子宫收缩的效力比前列腺素F2α和前列腺素E1高50 - 100倍或更多。观察到有轻微、短暂的胃肠道肌肉刺激活性，但膀胱压力和血压变化不明显。ONO - 802在怀孕动物中诱导的子宫收缩比未怀孕动物大10倍。这些结果表明，ONO - 802可能是一种适用于治疗性流产的临床前列腺素。
