Balzer C, Lotterer E, Kleber G, Fleig W E
First Department of Medicine, Martin-Luther-University Halle-Wittenberg, Germany.
Gastroenterology. 1998 Jul;115(1):167-72. doi: 10.1016/s0016-5085(98)70378-6.
Portal-hypertensive colopathy has attracted interest in recent years because such lesions can cause life-threatening hemorrhage. In contrast to upper gastrointestinal bleeding from varices, there is no established therapy for bleeding from angiodysplasia-like lesions. This case report describes the first successful use of transjugular intrahepatic portosystemic shunt (TIPS) for long-term control of bleeding from angiodysplasia-like colonic lesions in a patient with cirrhosis caused by chronic hepatitis B infection. During an 18-month course after TIPS, angiodysplasia-like lesions disappeared without any further evidence of recurrent hematochezia. TIPS may be helpful as second-line treatment in patients with recurrent portal-hypertensive bleeding from colonic angiodysplasia-like lesions who do not tolerate or are unresponsive to treatment with beta-adrenergic blockers.
近年来,门脉高压性结肠病引起了人们的关注,因为此类病变可导致危及生命的出血。与静脉曲张引起的上消化道出血不同,对于血管发育异常样病变引起的出血尚无既定的治疗方法。本病例报告描述了首例成功使用经颈静脉肝内门体分流术(TIPS)长期控制慢性乙型肝炎感染所致肝硬化患者血管发育异常样结肠病变出血的情况。在TIPS术后的18个月病程中,血管发育异常样病变消失,未再有便血复发的迹象。对于因结肠血管发育异常样病变导致门脉高压性出血复发且不耐受β - 肾上腺素能阻滞剂治疗或治疗无效的患者,TIPS作为二线治疗可能会有帮助。