一名男性的家族性C/D易位t(9;13)(9p23.13q21)与反复流产相关。
Familial C/D translocation t(9;13)(9p23.13q21) in a male associated with recurrent abortion.
作者信息
Singh-Kahlon D, Serra A
出版信息
Hum Genet. 1976 Aug 30;33(3):223-30. doi: 10.1007/BF00286846.
PMID:964984
Abstract
A familial reciprocal translocation, established by R-banding as t(9;13) (9p23;13q21), is described in a phenotypically normal male carrier, whose father is also a balanced carrier and wife had four consecutive spontaneous abortions. The role of translocation in reproductive failure through production of chromosomally unbalanced gametes or by impairment of the spermatogenesis is briefly discussed.
摘要
本文描述了一名表型正常的男性携带者，经R显带确定其存在家族性相互易位，核型为t(9;13) (9p23;13q21)。该男性的父亲也是平衡携带者，其妻子曾连续四次自然流产。本文简要讨论了易位通过产生染色体不平衡配子或损害精子发生在生殖失败中的作用。
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