Mino A, Page D, Dumont P, Broers B
Drug Alcohol Depend. 1998 May 1;50(3):233-9. doi: 10.1016/s0376-8716(98)00035-0.
The aim of this study was to identify predictors of treatment failure in a methadone maintenance treatment programme in Geneva. All patients (n = 149) starting treatment between May 1993 and May 1995 were followed until end of treatment or 31st July 1996. The proportion of depressed patients decreased significantly over time, as did the proportion of those injecting illegal drugs. The overall treatment failure was 21%. The probability of treatment failure was higher for women than for men (RR 2.2, P = 0.03) and decreased in successive cohorts. There was no correlation between the methadone dose at 2 months and treatment outcome, probably because doses were individualised and the associated level of psycho-social services high.
本研究的目的是确定日内瓦美沙酮维持治疗项目中治疗失败的预测因素。对1993年5月至1995年5月开始治疗的所有患者（n = 149）进行随访，直至治疗结束或1996年7月31日。随着时间的推移，抑郁患者的比例以及注射非法药物者的比例均显著下降。总体治疗失败率为21%。女性治疗失败的概率高于男性（相对危险度2.2，P = 0.03），且在连续队列中呈下降趋势。2个月时的美沙酮剂量与治疗结果之间无相关性，这可能是因为剂量是个体化的，且相关的心理社会服务水平较高。
