Coats W D, Faxon D P
Department of Medicine, University of Southern California, School of Medicine 90033, USA.
Semin Interv Cardiol. 1997 Sep;2(3):167-76.
The extracellular matrix is now recognized as a biologically active and dynamic composition of structural, adhesive, and counteradhesive fibrous proteins embedded in a hydrated ground substance of glycosaminoglycans and proteoglycans. The ability of resident cells to detect small differences in the specific combination, concentration and distribution of matrix components suggests that perturbation of the homeostatic matrix can lead to remodelling following angioplasty. Recent studies reviewed herein have focused on how alterations of the relative composition of matrix components ultimately leads to changes in cell growth, behaviour and differentiation, all of which can significantly contribute to remodelling of the vascular wall following injury. These cell-matrix interactions may provide novel therapeutic targets in the prevention of unfavourable remodelling that leads to restenosis.
细胞外基质现在被认为是一种具有生物活性的动态成分，由嵌入糖胺聚糖和蛋白聚糖水合基质中的结构、粘附和抗粘附纤维蛋白组成。驻留细胞能够检测基质成分的特定组合、浓度和分布中的微小差异，这表明稳态基质的扰动可导致血管成形术后的重塑。本文综述的近期研究集中于基质成分相对组成的改变如何最终导致细胞生长、行为和分化的变化，所有这些都可显著促进损伤后血管壁的重塑。这些细胞 - 基质相互作用可能为预防导致再狭窄的不良重塑提供新的治疗靶点。
