Galajda P, Martinka E, Baláz D, Stasko J, Kerný J, Planková E, Mokán M, Kubisz P
I. interná klinika, MFN Martin.
Vnitr Lek. 1997 Nov;43(11):744-7.
The authors examined 25 patients with diabetes mellitus type 2 (NIDDM) without vascular complications, treated by sulphonyl urea preparations, 12 hyperinsulinaemic (HI) non-diabetic subjects and 11 normoinsulinaemic healthy subject s. Patients with NIDDM and HI non-diabetics had significantly elevated PAI-1 levels which correlated with the C-peptide level (r = 0.519, p < 0.001), triacylglycerols (TG) (r = 0.685, p < 0.001), BMI (r = 0.607, p < 0.001) and levels of endothelial markers such as von Willebrand s factor and thrombomodulin (TM). In the group of patients with NIDDM no relationship of PAI-1 and C-peptide was found and a significant correlation was found with TM levels (r = 0.609, p = 0.001) and TG levels (r = 0.476, p = 0.046). The results suggest that the endothelial department has an effect on the regulation of PAI-1 levels in patients with NIDDM.
作者研究了25例无血管并发症的2型糖尿病（非胰岛素依赖型糖尿病）患者，这些患者接受磺脲类制剂治疗，12例高胰岛素血症（HI）非糖尿病受试者和11例正常胰岛素血症健康受试者。非胰岛素依赖型糖尿病患者和高胰岛素血症非糖尿病患者的纤溶酶原激活物抑制物-1（PAI-1）水平显著升高，且与C肽水平（r = 0.519，p < 0.001）、三酰甘油（TG）（r = 0.685，p < 0.001）、体重指数（BMI）（r = 0.607，p < 0.001）以及内皮标志物如血管性血友病因子和血栓调节蛋白（TM）水平相关。在非胰岛素依赖型糖尿病患者组中，未发现PAI-1与C肽之间的关系，而发现其与TM水平（r = 0.609，p = 0.001）和TG水平（r = 0.476，p = 0.046）存在显著相关性。结果表明，内皮部分对非胰岛素依赖型糖尿病患者PAI-1水平的调节有影响。
