Wakisaka Y, Taenaka Y, Chikanari K, Okuzono Y, Nishimura T, Endo S, Nakatani T, Takano H
Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
Artif Organs. 1998 Jun;22(6):493-7. doi: 10.1046/j.1525-1594.1998.06133.x.
An implantable centrifugal pump (ICP) 320 ml in volume and 830 g in weight has been developed for prolonged circulatory assist. The antithrombogenicity of the ICP is provided by a balancing hole in the center of the impeller. The watertightness and histocompatibility of the ICP are supported by its silicone ring seal and its casing of titanium and acrylic resin, respectively. The total efficiency of the ICP was 30% at a 5 L/min flow rate and a 100 mm Hg head. The heat generation, watertightness, and anatomical fitting of the ICP were assessed in an intrathoracic implantation in a goat (66 kg) and in an intraabdominal wall implantation in a goat (70 kg). Warfarin was given for anticoagulation in each experiment to keep the prothrombin time around 1.7 times that of the control. The temperatures of the pump surface, the pleura, and the room were measured every 3 h. Anatomical fitting was evaluated by pathological observation after the termination of the experiment. The ICP could run for 40 days in the chest cavity and for 11 days in the abdominal wall. The temperature of the motor remained about 1.8 degrees C higher than the reference in both experiments. The ICP was completely covered by a layer of smooth fibrous tissue. The moisture content of the seals remained normal. Although a small amount of atelectasis was found in the lingula, neither lung adhesion nor necrotic change of the chest wall was observed. The inflammation of the surrounding tissue including foreign body reaction and thermal burn was minimal. In conclusion, the ICP has satisfied in vivo testing of its watertightness, exothermicity, and anatomical fitting.
已研发出一种体积为320毫升、重量为830克的植入式离心泵（ICP），用于长期循环辅助。ICP的抗血栓形成性由叶轮中心的平衡孔提供。ICP的水密性和组织相容性分别由其硅胶环密封以及钛和丙烯酸树脂外壳来保障。在流速为5升/分钟、扬程为100毫米汞柱时，ICP的总效率为30%。在一只山羊（66千克）的胸腔植入以及另一只山羊（70千克）的腹壁植入中，对ICP的发热、水密性和解剖适配性进行了评估。每次实验中均给予华法林进行抗凝，以使凝血酶原时间维持在对照值的1.7倍左右。每3小时测量一次泵表面、胸膜和室温的温度。实验结束后，通过病理观察评估解剖适配性。ICP在胸腔中可运行40天，在腹壁中可运行11天。在两个实验中，电机温度均比参考温度高约1.8摄氏度。ICP完全被一层光滑的纤维组织覆盖。密封件的水分含量保持正常。尽管在舌叶发现少量肺不张，但未观察到肺粘连或胸壁坏死变化。包括异物反应和热灼伤在内的周围组织炎症极小。总之，ICP在水密性、放热性和解剖适配性方面的体内测试令人满意。
