Beijamini V, Skalisz L L, Joca S R, Andreatini R
Laboratório de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Eur J Pharmacol. 1998 Apr 17;347(1):23-7. doi: 10.1016/s0014-2999(98)00076-4.
The effect of oxcarbazepine was evaluated in two tests of depression (forced swimming and learned helplessness) and in the open-field test. Acute (three times over 24 h) oxcarbazepine 80 mg/kg (but not 40 mg/kg) decreased immobility time in the forced swimming test. In the learned helplessness test, 4 days of treatment with oxcarbazepine 80 mg/kg reversed the deficits induced by foot-shock in rats submitted to the two-way active avoidance test. Oxcarbazepine 80 mg/kg did not modify the behaviour of rats in the open-field test, an indication that, at this dose, oxcarbazepine did not show a locomotor stimulatory effect. Thus, the data of the present study suggest that oxcarbazepine has a potential antidepressive effect.
在两项抑郁测试（强迫游泳和习得性无助）以及旷场试验中评估了奥卡西平的效果。急性给予（24小时内三次）80毫克/千克奥卡西平（而非40毫克/千克）可减少强迫游泳试验中的不动时间。在习得性无助试验中，80毫克/千克奥卡西平治疗4天可逆转遭受双向主动回避试验的大鼠因足部电击所诱导的缺陷。80毫克/千克奥卡西平未改变大鼠在旷场试验中的行为，这表明在此剂量下奥卡西平未表现出运动刺激作用。因此，本研究数据表明奥卡西平具有潜在的抗抑郁作用。
