Bom N, Li W, van der Steen A F, Lancée C T, Céspedes E I, Slager C J, de Korte C L
Thoraxcentre, Erasmus University Rotterdam, The Netherlands.
Ultrasonics. 1998 Feb;36(1-5):625-8. doi: 10.1016/s0041-624x(97)00130-3.
Based on three-dimensional (3D) information, quantitative data such as plaque volume can be calculated. The procedure includes automatic contour detection based in image segmentation methods and greatly speeds up clinical evaluation. With the use of additional X-ray information, the true tortuous vessel geometry can be reconstructed in 3D. This allows, by numerical modelling techniques, to calculate endothelial shear stress values which in turn may indicate sites prone to stenosis. With a decorrelation technique for radio frequency (RF) echo information from sequential data in the same beam direction and integration method over the entire cross section, blood velocity can be shown colour-coded during the cardiac cycle, while even blood flow quantification seems to be possible. In vitro as well as animal experiments have shown the feasibility of the method. Intravascular imaging can be used to study the biomechanical properties of atheroma components. Local radial strain as a measure of local tissue hardness can be estimated in principle. Hard or soft plaques can be identified from the strain images independently of the echogenic contrast between plaque and vessel wall.
基于三维（3D）信息，可以计算诸如斑块体积等定量数据。该过程包括基于图像分割方法的自动轮廓检测，大大加快了临床评估速度。利用额外的X射线信息，可以重建真实的曲折血管几何形状。通过数值建模技术，这可以计算内皮剪切应力值，进而可能指示易发生狭窄的部位。利用同一波束方向上连续数据的射频（RF）回波信息的去相关技术以及整个横截面的积分方法，可以在心动周期中以彩色编码显示血流速度，甚至似乎可以进行血流定量分析。体外实验以及动物实验均已证明该方法的可行性。血管内成像可用于研究动脉粥样硬化成分的生物力学特性。原则上可以估计局部径向应变作为局部组织硬度的指标。可以从应变图像中识别硬斑块或软斑块，而与斑块和血管壁之间的回声对比无关。
