Suzuki Y, Ishihara R, Ishii Y, Nakazawa A, Deguchi K
Section of Studies, Tokyo Clinical Research Center.
Jpn J Antibiot. 1997 Nov;50(11):878-86.
We investigated antimicrobial activity of clindamycin (CLDM) against clinically isolated Streptococcus pneumoniae in 1996. The results are summarized as follows; 1. The detection frequencies of macrolides (MLs)-resistance against penicillin (PC)-susceptible S. pneumoniae (PSSP) was 48.0% and those against PC-intermediate S. pneumoniae (PISP)/ PC-resistant S. pneumoniae (PRSP) was 92.0%. 2. It was found that the ratio of MLs-inducible resistant strains of PSSP was 24.6% and that of PISP/PRSP was 66.0%. MLs-constitutive resistant strains of PSSP accounted for 24.0% and that of PISP/PRSP for 26.0%. MLs-constitutive resistant strains was relatively frequent in PSSP and MLs-inducible resistant strains was frequent in PISP/PRSP. 3. CLDM showed strong antimicrobial activity against MLs-inducible resistant strains. The MIC70 of CLDM against PSSP was < or = 0.025 microgram/ml and that against PISP/PRSP was 0.1 microgram/ml. From these results, it was suggested that CLDM is effective against the infection of PISP/PRSP where the detection frequency of MLs-inducible strains was high. 4. Antimicrobial activity of CLDM was found to be strong against MLs-inducible resistant strains, but to be weak against MLs-constitutive resistant strains. When S. pneumoniae is detected, susceptibility of the strain to CLDM should be examined.
1996年，我们研究了克林霉素（CLDM）对临床分离的肺炎链球菌的抗菌活性。结果总结如下：1. 对青霉素敏感的肺炎链球菌（PSSP）的大环内酯类（MLs）耐药检测频率为48.0%，对青霉素中介的肺炎链球菌（PISP）/青霉素耐药的肺炎链球菌（PRSP）的检测频率为92.0%。2. 发现PSSP的MLs诱导耐药菌株比例为24.6%，PISP/PRSP的比例为66.0%。PSSP的MLs组成型耐药菌株占24.0%，PISP/PRSP的占26.0%。MLs组成型耐药菌株在PSSP中相对常见，MLs诱导耐药菌株在PISP/PRSP中常见。3. CLDM对MLs诱导耐药菌株显示出强大的抗菌活性。CLDM对PSSP的MIC70≤0.025微克/毫升，对PISP/PRSP的MIC70为0.1微克/毫升。从这些结果表明，CLDM对MLs诱导菌株检测频率高的PISP/PRSP感染有效。4. 发现CLDM对MLs诱导耐药菌株的抗菌活性强，但对MLs组成型耐药菌株的抗菌活性弱。当检测到肺炎链球菌时，应检测该菌株对CLDM的敏感性。
