Arai C, Suzuki T
Department of Emergency Medicine, Tokyo Women's Medical College, Japan.
Jpn J Antibiot. 1997 Nov;50(11):887-96.
We investigated broncho-alveolar distribution of cefepime (CFPM), a fourth generation cephem, using 38 BALF specimens from 19 serious pneumonia patients who underwent artificial respiratory system control. The mean broncho-alveolar CFPM level was 3.44 microgram/ml (5.34% of the mean peak blood level). We thus observed that the BALF level after a single dose of 1 g of CFPM exceeds the MIC90 of the drug against RTI causing bacteria such as Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophillus influenzae, Branhamella catarrhalis, coagulase-negative Staphylococcus, Pseudomonas aeruginosa and Staphylococcus aureus.
我们使用了19例接受人工呼吸系统控制的重症肺炎患者的38份支气管肺泡灌洗（BALF）标本，研究了第四代头孢菌素头孢吡肟（CFPM）在支气管肺泡中的分布情况。支气管肺泡CFPM平均水平为3.44微克/毫升（为平均血药峰浓度的5.34%）。因此我们观察到，单次静脉滴注1克CFPM后，BALF中的药物浓度超过了该药对引起呼吸道感染（RTI）的细菌，如肺炎链球菌、肺炎克雷伯菌、流感嗜血杆菌、卡他莫拉菌、凝固酶阴性葡萄球菌、铜绿假单胞菌和金黄色葡萄球菌的MIC90。
