转录调控：反式激活因子（Tat）辅因子与转录延伸
Transcriptional control: Tat cofactors and transcriptional elongation.
作者信息
Yankulov K, Bentley D
机构信息
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
出版信息
Curr Biol. 1998 Jun 18;8(13):R447-9. doi: 10.1016/s0960-9822(98)70289-1.
PMID:9651670
Abstract
HIV-1 gene expression requires the transactivator Tat, which stimulates viral transcript elongation. Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit, contact Tat and contribute to the control of transcriptional elongation.
摘要
HIV-1基因表达需要反式激活因子Tat，它能刺激病毒转录延伸。最近的研究结果表明，两种细胞周期蛋白依赖性激酶可磷酸化RNA聚合酶II大亚基的羧基末端结构域，它们与Tat接触并参与转录延伸的调控。
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