Lederman M M, Connick E, Landay A, Kuritzkes D R, Spritzler J, St Clair M, Kotzin B L, Fox L, Chiozzi M H, Leonard J M, Rousseau F, Wade M, Roe J D, Martinez A, Kessler H
Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Ohio 44106, USA.
J Infect Dis. 1998 Jul;178(1):70-9. doi: 10.1086/515591.
Human immunodeficiency virus (HIV)-1 infection is associated with progressive cell-mediated immune deficiency and abnormal immune activation. Although highly active antiretroviral therapy regimens can increase circulating CD4 T lymphocyte counts and decrease the risk of opportunistic complications, the effects of these treatments on immune reconstitution are not well understood. In 44 persons with moderately advanced HIV-1 infection, after 12 weeks of treatment with zidovudine, lamivudine, and ritonavir, plasma HIV-1 RNA fell a median of 2.3 logs (P < .0001). Circulating numbers of naive and memory CD4 T lymphocytes (P < .001), naive CD8 T lymphocytes (P < .004), and B lymphocytes (P < .001) increased. Improved lymphocyte proliferation to certain antigens and a tendency to improvement in delayed-type hypersensitivity also were seen. Dysregulated immune activation was partially corrected by this regimen; however, the perturbed expression of T cell receptor V regions in the CD4 and CD8 T lymphocyte populations was not significantly affected. Ongoing studies will ascertain if longer durations of virus suppression will permit more complete immune restoration.
人类免疫缺陷病毒1型（HIV-1）感染与进行性细胞介导免疫缺陷及异常免疫激活相关。尽管高效抗逆转录病毒治疗方案可增加循环CD4 T淋巴细胞计数并降低机会性并发症风险，但这些治疗对免疫重建的影响尚不清楚。在44例中度晚期HIV-1感染患者中，接受齐多夫定、拉米夫定和利托那韦治疗12周后，血浆HIV-1 RNA中位数下降2.3个对数（P < 0.0001）。幼稚和记忆性CD4 T淋巴细胞（P < 0.001）、幼稚CD8 T淋巴细胞（P < 0.004）及B淋巴细胞（P < 0.001）的循环数量增加。还观察到淋巴细胞对某些抗原的增殖改善以及迟发型超敏反应有改善趋势。该治疗方案部分纠正了失调的免疫激活；然而，CD4和CD8 T淋巴细胞群体中T细胞受体V区的异常表达未受到显著影响。正在进行的研究将确定更长时间的病毒抑制是否能实现更完全的免疫恢复。
