Drazen J M, Loring S H, Ingram R H
J Appl Physiol. 1976 Sep;41(3):396-9. doi: 10.1152/jappl.1976.41.3.396.
The relationship between the major site of airway constriction and change in total pulmonary resistance while breathing gases of varying density and viscosity was studied in five anesthetized dogs pretreated with atropine. Using an airway catheter, central and peripheral components of pulmonary resistance were measured by forced oscillation. Total pulmonary resistance was measured at 0.5 1/s with lungs air-filled, at 0.25 1/s with the lungs filled with 80% helium-20% oxygen (RL-He), and at 1.0 1/s with 80% sulfur hexafluoride-20% oxygen (RL-SF6). Intravenous histamine infusion resulted in a predominantly peripheral resistance increase as determined by the airway catheter and a much larger percentage increase in RL-He than in RL-SF6. Tracheal banding produced a purely central resistance increase and a greater change in RL-SF6 than in FL-He. These results support theoretical predictions that the predominant site of airways constriction can be determined without on airway catheter by comparing relative changes in total pulmonary resistance using different flow regimes.
在五只经阿托品预处理的麻醉犬中，研究了在呼吸不同密度和粘度的气体时，气道收缩的主要部位与总肺阻力变化之间的关系。使用气道导管，通过强迫振荡测量肺阻力的中央和外周成分。在肺充气时以0.5升/秒测量总肺阻力，在肺充入80%氦-20%氧时以0.25升/秒测量（RL-He），在充入80%六氟化硫-20%氧时以1.0升/秒测量（RL-SF6）。静脉输注组胺导致主要是外周阻力增加，这由气道导管确定，且RL-He中的增加百分比比RL-SF6中的大得多。气管结扎产生纯粹的中央阻力增加，且RL-SF6中的变化比FL-He中的更大。这些结果支持理论预测，即通过使用不同的流态比较总肺阻力的相对变化，可以在不使用气道导管的情况下确定气道收缩的主要部位。
