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鼻窦炎的颅内并发症:一项儿科病例系列研究

Intracranial complications of sinusitis: a pediatric series.

作者信息

Giannoni C, Sulek M, Friedman E M

机构信息

Department of Otolaryngology, University of Florida, Gainesville, USA.

出版信息

Am J Rhinol. 1998 May-Jun;12(3):173-8. doi: 10.2500/105065898781390127.

Abstract

Intracranial complications of sinusitis (ICS) (cerebral, epidural, and subdural abscesses, meningitis, and dural sinus thrombophlebitis) remain a challenging and contemporary topic. The progressive pneumatization and continued development of the sinuses after birth and the late appearance of the frontal and sphenoid sinuses imply that some infections would not appear until later childhood. We reviewed the records at a large pediatric hospital between 1986 and 1995 and found 10 children with 13 ICS (cerebral abscess, 5; extra-axial empyema, 5; and meningitis, 3). Of 43 children with cerebral abscess and 16 with extra-axial abscesses treated in this period, 12% of cerebral and 63% of extra axial abscesses were due to a sinogenic source. Multiple intracranial and extracranial complications of sinusitis in a single patient were common. The average age of children with ICS was 12.2 years old. We present these 10 cases and discuss their presentation, microbiology, and clinical course. Although the majority presented with a classic picture of headache, altered mental status, and fever, a few had symptoms that were more subtle. One child had recurrent meningitis, believed to be due to skull base dehiscence after endoscopic sinus surgery (ESS). He has required multiple otolaryngologic and neurosurgical procedures in an effort to prevent further episodes of meningitis. Ultimately, nine of 10 patients survived with an average hospital stay of 27.8 days (median of 17 days). The diagnosis of ICS requires a high index of suspicion, imaging of the brain and paranasal sinuses, and aggressive intervention.

摘要

鼻窦炎的颅内并发症(ICS)(脑脓肿、硬膜外脓肿、硬膜下脓肿、脑膜炎和硬脑膜窦血栓性静脉炎)仍然是一个具有挑战性的当代课题。出生后鼻窦的渐进性气化和持续发育以及额窦和蝶窦的较晚出现意味着一些感染直到儿童后期才会出现。我们回顾了一家大型儿科医院1986年至1995年期间的记录,发现10名儿童患有13例ICS(脑脓肿5例;轴外积脓5例;脑膜炎3例)。在此期间治疗的43例脑脓肿患儿和16例轴外脓肿患儿中,12%的脑脓肿和63%的轴外脓肿源于鼻窦。单一患者出现多种颅内和颅外鼻窦炎并发症很常见。患有ICS的儿童平均年龄为12.2岁。我们展示这10例病例并讨论其临床表现、微生物学和临床病程。尽管大多数患者表现为典型的头痛、精神状态改变和发热,但少数患者的症状更为隐匿。一名儿童反复发生脑膜炎,据信是由于内窥镜鼻窦手术(ESS)后颅底裂开所致。为防止脑膜炎进一步发作,他需要多次接受耳鼻喉科和神经外科手术。最终,10名患者中有9名存活,平均住院时间为27.8天(中位数为17天)。ICS的诊断需要高度的怀疑指数、脑部和鼻窦的影像学检查以及积极的干预。

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